March 4, 2019, MedPage Today 

WASHINGTON -- Injectable collagenase clostridium histolyticum (CCH) was an effective treatment option for women with cellulite on the buttocks, according to researchers here.

Based on results from two randomized, double-blind, placebo-controlled, phase III trials (Release-1 and Release-2), CCH (Xiaflex) significantly improved cellulite severity in women with moderate to severe cellulite on the buttocks, reported Joely Kaufman, MD, of the Skin Associates of South Florida in Coral Gables, and colleagues, at the American Academy of Dermatology meeting.

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March 4, 2019, MedPage Today OB/GYN Update 

Pregnancies shortly after a stillbirth were not linked with an increased risk of adverse outcomes compared to those where women waited longer to conceive, researchers found.

In a study of over 14,000 women who had a stillbirth, pregnancy intervals ≤12 months were not associated with a higher risk of subsequent stillbirth, preterm birth, or small-for-gestational-age birth compared with intervals of 24-59 months following a stillbirth, reported Annette Regan, PhD, of Curtin University in Perth, Australia, and colleagues in The Lancet.

March 4, 2019, MedPage Today  

Women with advanced ovarian cancer and clinically negative lymph nodes at surgery did not live longer if they underwent pelvic and paraaortic lymphadenectomy, final results of a randomized trial showed. 

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March 1, 2019, MedPage Today 

The identification of biomarkers to cluster breast cancer patients into subgroups based on their immune evasion mechanisms may help guide the choice of immunotherapy, according to new research. The findings provide a better understanding of the response to immunotherapies and shed light on the rational design of novel combination therapies, the team said. 

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March 1, 2019, Cardiology Today 

BMI increased more and total cholesterol decreased less in women compared with men during a 15-year period, according to an analysis of temporal trends in CV risk factor levels. The researchers assessed sex differences in temporal trends for risk factors, including systolic BP, BMI, smoking status, and HDL and total cholesterol. Trends in treatment and control rates of hypertension, diabetes, and dyslipidemia were also analyzed. 

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March 1, 2019, HealthDay News via Monthly Prescribing Reference 

The battle against new HIV infections has lost some steam in recent years, according to the U.S. Centers for Disease Control and Prevention. After about five years of significant declines, the number of new HIV infections began to level off in 2013, at about 39,000 infections per year. The reason for the slowing, according to the CDC, is that effective HIV prevention and treatments are not reaching those who could most benefit. These shortfalls in prevention and treatment are most glaring in rural areas and in the South, and they disproportionately affect blacks and Hispanics. 

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March 1, 2019, HemOnc Today 

Sacituzumab govitecan induced durable responses in patients with heavily pretreated metastatic triple-negative breast cancer, according to results of a phase 1/2 single-group trial published in The New England Journal of Medicine. The antibody-drug conjugate also appeared safe among these patients, who achieved better outcomes than those associated with standard chemotherapy for triple-negative disease. 

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March 1, 2019, MedPage Today

When introduced on a nationwide basis, minimally invasive robotic surgery is associated with the performance of a greater proportion of minimally invasive procedures, as well as improved outcomes in patients with early-stage endometrial cancer, Danish investigators found. Specifically, this change in surgical approach leads to a significantly reduced risk of severe complications in these patients.

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March 1, 2019, HealthDay News 

For older adults with a urinary tract infection (UTI), antibiotic treatment should begin immediately to prevent serious complications, a new British study finds. Delaying or withholding antibiotics in this age group can increase the risk of bloodstream infection (sepsis) and death, researchers reported Feb. 27 in the BMJ. 

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February 28, 2019, MedPage Today  

Autism was less likely to recur in high-risk families when mothers took prenatal vitamins -- particularly folic acid and perhaps iron as well -- in the first month of their pregnancy, an analysis of MARBLES study data found. 

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