August 25, 2019 - MedPage Today

Per the final two-part recommendation published at the USPSTF website and in JAMA, assessments for increased risk of BRCA1 and BRCA2 genetic mutations should be conducted in women who have a personal or family history of certain types of cancers (breast, ovarian, fallopian tube, or peritoneal cancers), or who have an ancestry associated with BRCA1 or BRCA2 mutations. Women found to be at increased risk should receive genetic counseling and, if indicated after counseling, BRCA testing. The first part of the recommendation received a 'B' grade, meaning a "high certainty that the net benefit is moderate or there is moderate certainty that the net benefit is moderate to substantial."

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